منابع مشابه
Unanticipated role of apelin: regulation of miRNA generation.
Recently, a paper by Kim et al. [1] in Nature Medicine magazine in January, 2013 showed that apelin (also known as APLN) inhibits fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1) expression to ameliorate pulmonary hypertension by regulating the expression of miR-424 and miR-503. This study revealed the molecular mechanism of apelin in inhibiting the process of pulmonary arterial hyp...
متن کاملA genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance
RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres, although its role in telomere length maintenance and protection has remained elusive. RAP1 also binds subtelomeric repeats and along chromosome arms, where it regulates gene expression and has been shown to function in metabolism control. Telomerase is the enzyme that elongates telomeres, and its de...
متن کاملUnanticipated Software Evolution
1 Dept. of Computer Science III, University of Bonn, Germany, [email protected] http://www.cs.uni-bonn.de/∼gk/ 2 Software Engineering Lab, University of Twente, Enschede, The Netherlands, [email protected] http://wwwhome.cs.utwente.nl/∼noppen/ 3 Programming Technology Lab, Vrije Universiteit Brussel, Belgium, [email protected] http://prog.vub.ac.be/∼tommens/ 4 University of Limerick, Castle...
متن کاملThe enterococcal cytolysin synthetase has an unanticipated lipid kinase fold
The enterococcal cytolysin is a virulence factor consisting of two post-translationally modified peptides that synergistically kill human immune cells. Both peptides are made by CylM, a member of the LanM lanthipeptide synthetases. CylM catalyzes seven dehydrations of Ser and Thr residues and three cyclization reactions during the biosynthesis of the cytolysin large subunit. We present here the...
متن کاملNasotracheal intubation in patients with an unanticipated difficult airway--I.
To the Editor: We read, with interest, the recent case report written by Drs. Uria et al.1, and we agree with their assessment that it is important to perform a preliminary laryngoscopy prior to inserting a nasal tube. However, their recommendation to insert a bougie through the RAE® nasal tube, with its distal acute curve, can result in inappropriate bending of the distal portion which is unfa...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2009
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2749